Research group Integrated Separation Processes

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Head of group: Prof. Dr.-Ing. habil. Malte Kaspereit

Research statement

The research group Integrated Separation Processes develops advanced concepts for highly topical and challenging separation problems. Special focus is on integrated processes. These purposefully combine different separation techniques with other separation and/or reaction techniques, either in single apparatuses or as setups of closely combined units with recycles. Designed in an optimal manner, such processes may achieve a drastically improved performance in comparison to conventional sequences of unit operations.

We study Example: Process combination that produces a pure enantiomer from a racemate at 100% yieldboth hybrid processes as well as reactive separations. Here the term "hybrid" refers to process configurations of closely connected units with additional recycles. Such processes raise interesting challenges regarding their optimal design and dynamic behavior.

Process development is performed systematically and strongly model-driven using state-of-the-art tools for simulation and optimization. To support application of developed processes, shortcut design methods are developed using, for example, local equilibrium theory of chromatography.
Scope of experimental investigations is on parameter determination and proof-of-concept.

Investigated technologies include chromatographic and adsorptive separations, membrane processes, crystallization, as well as reactions. Particular expertise is being held in sophisticated chromatographic concepts, including various variants of simulated moving bed and steady-state recycling chromatography.

Applications areas were so far mainly in the field of fine chemicals and pharmaceuticals, in particular related to chiral separations. Currently, also problems from downstream processing of biomolecules, nanoparticles, gas separation and utilization of alternative energy sources are being explored.

Offered services

The group offers services regarding the development and design of separation processes, in particular on the basis of the unit operations mentioned above. This includes process modelling, simulation, design, performance evaluation, as well as experimental parameter determination and full characterization of corresponding applications.

Team members

Malte Kaspereit
Alexander Günther
Bilal Haider
Kathleen Müller
Johannes Schmölder
Jürgen Vargas Schmitz

Selected publications (complete list)

D. Flockerzi, M. Kaspereit, A. Kienle:
Spectral properties of Bi-Langmuir isotherms,
Chemical Engineering Science (in press).

J. Kiefer, M. Kaspereit:
Determination of the Raman depolarization ratio in optically active samples,
Analytical Methods 5 (2013) 797-800.

S. Nimmig, M. Kaspereit:
Continuous Production of Single Enantiomers at High Yields by Coupling Single Column Chromatography, Racemization, and Nanofiltration,
Chemical Engineering & Processing: Process Intensification 67 (2013) 89-98.

S. Swernath, M. Kaspereit, A. Kienle:
Dynamics and Control of Coupled Continuous Chromatography and Crystallization Processes for the Production of Pure Enantiomers,
Chemical Engineering & Technology 36 (2013) 1417-1429.

M. Kaspereit, S. Swernath, A. Kienle:
Evaluation of competing process concepts for the production of pure enantiomers,
Organic Process Research & Development 16 (2012) 353-363.

B. Sreedhar, A. Wagler, M. Kaspereit, A. Seidel-Morgenstern:
Optimal cut-times finding strategies for collecting a target component from overloaded elution chromatograms,
Computers & Chemical Engineering 49 (2013) 158-169

M. Kaspereit, T. Sainio:
Simplified Design of Steady-State Recycling Chromatography Under Ideal and Nonideal Conditions,
Chemical Engineering Science
66 (2011) 5428-5438.

J. G. Palacios, M. Kaspereit, A. Kienle:
Integrated Simulated Moving Bed Processes for the Production of Single Enantiomers,
Chemical Engineering & Technology
34 (2011) 688-698.

T. Sainio, M. Kaspereit:
Analysis of steady state recycling chromatography using equilibrium theory,
Separation & Purification Technology 66 (2009) 9-18.

M. Kaspereit, A. Seidel-Morgenstern, A. Kienle:
Design of Simulated Moving Bed Chromatography Under Reduced Purity Requirements,
Journal of Chromatography A 1162 (2007) 2-13.

M. Kaspereit, K. Gedicke, V. Zahn, A.W. Mahoney, A. Seidel-Morgenstern:
Shortcut Method for Evaluation and Design of a Hybrid Process for Enantioseparations,
Journal of Chromatography A 1092 (2005) 55-64.

H. Schramm, A. Kienle, M. Kaspereit, A. Seidel-Morgenstern:
Improved Operation of Simulated Moving Bed Processes through Cyclic Modulation of Feed Flow and Feed Concentration,
Chemical Engineering Science 58 (2003) 5217-5227.