Research group Chromatography and Adsorption

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Head of group: Dr. Mirjana Minceva

The overall objective of the group Chromatography and Adsorption is the development of efficient chromatographic and adsorption processes and concepts for separation of fine chemicals and life science products. This is realized by the use of innovative approaches to study the phenomena governing the separation efficiency, thermodynamic models for the prediction of the phase equilibrium, unconventional stationary phases (liquid stationary phases and monoliths), and continuous separation concepts.

The group features the abilities for performing in silico experiments, process design and optimization using in-house developed programs, implemented in gPROMS™, STAR CD™ and MATLAB. The equipment at hand includes: 2 analytical HPLC devices, 4 preparative batch systems, 2 Simulated Moving Bed (SMB) units, batch and continuous Centrifugal Partition Chromatographic (CPC) unit.

The current research activities are divided in two main topics: Liquid-liquid chromatography and Solid-liquid chromatography.

Liquid-liquid chromatography (Centrifugal Partition Chromatography)

Development of a method for selection of mobile and stationary phase in Centrifugal Partition Chromatography (Dipl.-Ing. Andreas Frey)

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Continuous Centrifugal Partition Chromatography (Dipl.-Ing. Elisabeth Hopmann)

Project: “True Moving Bed Centrifugal Partition Chromatography Unit” (DFG Großgeräte-Projekt INST 90/9551 FUGG)

Solid-liquid chromatography

Study of flow distribution in packed columns by X-ray computed tomography (Dipl.-Ing. Irma Schmidt)

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Project: “Hydrodynamische Auslegung technischer flüssigchromatographischer Säulen mittels CT-Messungen” (DFG 7559 091)

Project: “Computertomographieanlage” (Großgeräte-Projekt INST 90/692-1 FUGG)

Recovery of high added value products from complex mixtures using Simulated Moving Bed technology (Dipl.-Ing. Kiara Kochendörfer)

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Project: "Entwicklung einer Anwendungsoption der Simulated-Moving-Bed Technologie (SMB) für die Herstellung von innovativen natürlichen Citrusflavourbausteinen” (ZIM Kooperationsprojekt KF 23479050H9)